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Among the numerous cell types composing the epithelial layer are goblet cells which secrete glycosylated Mucin-2 (Muc2), a key component of the intestinal mucosal layer (Brenchley and Douek 2012

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However, the energy deficit hypothesis fails to fully account for a key clinical feature of PEM: the significant decline in muscle strength (myasthenia) upon the initial contraction after sufficient rest, rather than solely following endurance activities (83)

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