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373 PRESENCE OF METABOLIC COMORBIDITIES INCREASES THE RISK OF HEPATOCELLULAR CARCINOMA IN SUB-SAHARAN AFRICAN INDIVIDUALS LIVING WITH CHRONIC HEPATITIS B Lesley Patmore 1 Kirsi van Eekhout 2 Maria Buti 3 zgr Muhammet Koc 4 Kosh Agarwal 5 Robert De Knegt 1 Harry Janssen 1 Marc van der Valk 2 Faydra Lieveld 6 Matthijs Kramer 7 Joep de Bruijne 6 Mark Claassen 8 Colette Smit 9 Robert De Man 10 Bart Takkenberg 11 Ivana Carey 5 Milan Sonneveld 10 , 1 Erasmus MC, 2 Amsterdam UMC, 3 Hospital Valle Hebron, 4 Maastricht UMC+, 5 King's college Hospital, 6 UMC utrecht, 7 Maastricht UMC, 8 Rijnstate Hospital, 9 HIV monitoring Foundation Amsterdam, 10 Erasmus University Medical Center, 11 Amsterdam University Medical Centers, location AMC Background: Recent studies have identified metabolic comorbidities (MC) as risk factors for hepatocellular carcinoma (HCC) in individuals with chronic hepatitis B (CHB)

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Mitochondrial dysfunction is a key feature of many neurodegenerative diseases, including Parkinsons and Alzheimers disease

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