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In normal kidney function the counter current multiplier system, together with the renin-angiotensin-aldosterone system (RAAS), involves extracellular fluid volume control, electrolyte balance, waste product excretion, drug and hormone elimination/metabolism, blood pressure (BP) and haematocrit regulation, and calcium/phosphate balance (vitamin D 3 metabolism)

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Waist circumference improvements were also greater with the higher dose, with an average additional reduction of nearly 12 cm or 4.72 inches compared to placebo

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