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In addition to observing an important reduction of the tumour mass and volume as a result of the treatment with a hydroethanolic extract of the plant, we noted a remarkable modulation of the oxidative stress caused by the neoplastic process, both in the liver and in the tumour of the subjects [19]

Lipoic acid downmodulates CD4 from human T lymphocytes by dissociation of p56(Lck) Biochem Biophys Res Commun

Among the main obstacles, particularly concerning oral administration, are low solubility, reduced intestinal absorption, hepatic first-pass metabolism, degradation during gastrointestinal transit, interactions with the food matrix, and high individual variability, including the influence of the intestinal microbiota [50]

& Febbraio, M