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The copper content of GHK-Cu formulations has been a theoretical safety consideration, given that excessive copper can be toxic - however, the amounts used in cosmetic and research applications are extremely small, the copper is tightly chelated by the peptide (reducing free copper availability), and topical absorption of copper from these products appears minimal and well below levels that would cause systemic copper accumulation or toxicity

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Men with active cancer or certain cancer histories should avoid peptide therapy unless cleared by their oncologist or specialist, because some peptides may influence growth hormone, IGF-1, or cellular growth pathways