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Interaction between A and Tau in the Pathogenesis of Alzheimers Disease

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260,261 The Neh2 domain contains two motifs (i.e., DLG and ETGE), which are essential for the interaction between Nrf2 and its negative regulator, Kelch-like ECH associated protein (Keap) 1

Supporting this, Wang et al (110) found that TSA notably improved cardiac function in two-kidney, two-clip (2K2C) hypertensive rats [reducing left ventricular end-diastolic pressure and increasing ejection fraction and left ventricular fractional shortening (LVFS)], while attenuating myocardial hypertrophy and fibrosis, independent of its antihypertensive effect (no notable impact on blood pressure) (110)