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The significant downregulation of TFAM, COX10, and COX5A, among other mitochondria-related proteins, highlights the critical role of PGC-1 in maintaining mitochondrial function

Another research found that NRC-03 and NRC-07, the two AMPs from the pleurocidin AMP family, can also reverse the sensitivity of multidrug-resistant breast cancer MDA-MB-231 cells to some chemotherapeutic drugs

Moreover, L18 consortia exhibited a cooperative advantage over L6 consortia

Dose-dependently improved organ coefficients (reduced liver coefficient, increased cardiac and kidney coefficients) and reduced tissue damage (cardiomyocyte degeneration, kidney glomerular/tubular damage, hepatocyte ballooning, pancreatic islet loss) in db/db mice, with 500 mg/kg treatment more effective than metformin

Ryan J, Croft K, Mori T, et al