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Overexpression of the transcript variant significantly enhanced proliferation of normal HPCs

some researchers speculate that 7-HMR, like other plant lignans, can act as a phytoestrogen and thereby modulate inflammatory pathways linked to hormonal signaling (63)

In lung cancer cells, SHMT1 knockdown induces cell cycle arrest, leading to p53-dependent apoptosis

Tanaka T, Shnimizu M, Molecules HM-, 2012 undefined

[6] SAM may act as a methyl donor in the metabolic processes that control lipid homeostasis, DNA stability, gene expression, and neurotransmitter release, which may account for the benefits it confers