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[PubMed: 27468060] 32

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Thirty-five (59.3%) were treated with insulin and 1 (1.7%) used pioglitazone

The elevation of these three intermediates contributes to various reactions that converge on oxidative stress: G-6-P and GAP can undergo autoxidation, leading to the formation of AGE precursors

The findings were notable for the effective doses (low milligram per kilogram in rats), the oral route of administration (most peptides require injection), and the magnitude of cognitive rescue