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Researchers have attempted to elucidate the underlying mechanisms of DCM, which are usually treated as determinants of uncontrollable persistent pathological changes, such as aberrant hyperglycemia, insulin resistance, excessive oxidative stress, inflammatory response, and mitochondrial dysfunction [7,8,9]

R76 is also a highly conserved residue, indicating the potential important role of this methylation event in various mammalian species (Fig

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Each compound addresses distinct physiological challenges associated with metabolic optimization, and together they create a more comprehensive approach than either achieves independently

This review describes the potential role of SGLT2 inhibitors as a breakthrough therapeutic option in PD, emphasizing their ability to address unmet clinical needs and improve patient outcomes