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Schliebs R, et al

This treatment regimen led to a reduction in blood-brain barrier (BBB) permeability, edema, and neuronal apoptosis, ultimately resulting in an enhancement of the subjects neuroscores (Kerman et al., 2012

The interaction theory assumes the formation of chemical bonds between water and the hydrophilic groups within the polymer network 29,30

Because the target range is the condition at which optimization of desired efficacy converges with acceptable toxicity risk, the time in target range (TTR) should be maximized

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