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PMID: 41447318 JCI InsightSPOP mediates apoptosis and protects against necroptosis by regulating ubiquitination of RIPK1 and RIPK3

This treatment method shows great potential in the field of cancer treatment because of its advantages of high efficiency, strong selectivity and stimulating immune system

More than 90% of PDAC cases harbor mutations in KRAS and mutant KRAS signaling is linked to increased ROS production and, therefore, increased dependency on cystine import via SLC7A11