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5 Modern colorimetric detection methods are rapid, sensitive, portable, and affordable, thus making the sensing process available for various scenarios including clinical laboratories, 6 industrial environments, 7 agricultural areas, 8 residential spaces, 9 and public transit systems

However, there are still challenges that need to be addressed, such as the optimization of properties, reliable characterization methods, safety evaluation, nanoparticles that might lead to unintended consequences like nano-pollution and cytotoxicity and regulatory aspects related to nanomedicines targeting skin cancer [176, 179]

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Challenges of regulated cell death: implications for therapy resistance in cancer

Therefore, SH compounds, reducing agents and SH reactive materials should be avoided during the sample preparation