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The recruitment of CD8 + T cells in the LS-CRC tumour is likely due to the observed elevated expression of a number of CD8 + T cell-mobilizing chemokines in the tumour microenvironment (data not shown), coupled with the high neoantigen burden and increased immunogenic peptides noted in this patient (II.2

Tirzepatide can cause acute kidney injury, particularly with severe gastrointestinal symptoms causing dehydration

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