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Glutathione also plays a role in inflammation as the ratio between oxidized and reduced glutathione in the body is indicative of not only overall toxicity, but also inflammatory response

This imbalance renders granulosa cells vulnerable to ferroptosis, which can impair estrogen synthesis and disrupt follicular development ( - expression and promoting lipid peroxidation, ultimately triggering ferroptosis ( Notably, androgen excess, a hallmark of PCOS, may also contribute to ferroptosis

J.KimJ.et al

Immune System Resilience Your immune cells, such as T-cells and lymphocytes, require a high concentration of glutathione to function properly

Erastin can elevate the level of HSP90, a molecular chaperone, which partially accentuates ferroptosis by amplifying GPX4 autophagic degeneration[169]