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All procedures were conducted following the ethical standards and guidelines for laboratory animals set by the Peoples Republic of China and the Declaration of Helsinki

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These observations indicate that DMFs activation of NRF2 originates not only from inducing NRF2 in the cytoplasm but also from inhibiting the NRF2 repressor in the nucleus

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This metabolic disruption contributes to the formation of amyloid plaques and tau pathology 195,196