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J Reprod Med 2008;53:161-165 Laufer MR, Sanfilippo J, Rose G

Elevated levels of plasma glucose and free fatty acids increase mitochondrial superoxide production [78]

Orally ingested aspartame components are immediately absorbed from the lumen and reach the portal blood in a manner similar to that of amino acids arising from dietary protein or polysaccharides.4,5 Their concentrations are found increased in the blood stream.6 This sweetener and its metabolic breakdown products (phenylalanine, aspartic acid and methanol) have been a matter of extensive investigation for more than 20 years, including experimental animal studies

In human lens epithelial cells, 50250 M melatonin decreases H2O2-induced intracellular ROS generation by activating the PI3K/Akt signaling pathway (114) and inhibits UVB-promoted ferroptosis by regulating two Sirt6 (Nrf2 or nuclear receptor coactivator 4) pathways (115,116)

Berberine can also help by increasing sex hormonebinding globulin (SHBG), which binds to free testosterone and helps keep it in check