igf-1 lr3 reduce hypoglycemia injection pain desensitization IGF/IGF-1R signal pathway in pain: a promising therapeutic target About IGF-1R | Lonigutamab |

While increased oxidative stress is a major molecular underpinning of CKD progression, no treatment modality specifically targeting oxidative stress has been established clinically

Br J Clin Pharmacol 83, 163171

8 , eabo6574 (2022)

Pecot CV, Wu SY, Bellister S, Filant J, Rupaimoole R, Hisamatsu T, Bhattacharya R, Maharaj A, Azam S, Rodriguez-Aguayo C, Nagaraja AS, Morelli MP, Gharpure KM, Waugh TA, Gonzalez-Villasana V, Zand B, Dalton HJ, Kopetz S , Lopez-Berestein G, Ellis LM, Sood AK

HIF-1, a glycolytic master transcriptional regulator that transactivates several glycolytic genes, is upregulated in IPF and represents a potential target for fibrosis treatment (144,145)