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Abbreviations CALCOCO2: Calcium binding and coiled-coil domain-containing protein 2 DPP: Diabetes Prevention Program ECM: Extracellular matrix ER: Endoplasmic reticulum GLP-1: Glucagon-like peptide-1 GWAS: Genome-wide association studies HNF1A: Hepatocyte nuclear factor 1- IGT: Impaired glucose tolerance ITFG3: Integrin FG-GAP repeat containing 3 PE: Pancreatic elastase SIDD: Severe insulin-deficient diabetes TMAO: Trimethylamine N -oxide UPR: Unfolded protein response References Esser N, Utzschneider KM, Kahn SE (2020) Early beta cell dysfunction vs insulin hypersecretion as the primary event in the pathogenesis of dysglycaemia

An RCT investigated the effect of 5 mg/d folic acid, the combination of 5 mg/d folic acid and 80 mg/d pyridoxin, and placebo for 3 months

Safety, efficacy, and biomarker findings of PBT2 in Alzheimers disease: a randomized, double-blind, placebo-controlled phase IIa study

Li J-h, Chen Y, Ye Z-h, Chen L-p, Xu J-x, Han J et al (2024) Suppression of MyD88 disturbs gut microbiota and activates the NLR pathway and hence fails to ameliorate DSS-induced colitis

YDYXJJ2025-0024), the Yunnan University Graduate Research Innovation Fund (No