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Its hallmark pathological features including cartilage degradation, subchondral bone sclerosis, osteophyte formation and synovial inflammation, are fueled by a complex interplay of inflammatory cascades, oxidative stress, and mechanical stress imbalance (57)

As rehabilitation progresses and active training resumes (typically 8-12 weeks post-surgery depending on the procedure), the protocol transitions to maintenance dosing with cryotherapy reserved for higher-intensity training days

Expect 8-12+ weeks for meaningful improvement with chronic conditions, and results may be more modest compared to acute injuries

E.DelheyL.SlatteryJ.TippettM.WynneR.RoseS.et al

Wells, W