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(2015), it was shown that excessive mitochondrial fission induced by Drp1 activation leads to increased production of mitochondrial ROS, which activates the NLRP3 inflammasome, promoting inflammation (Park et al., 2015)

Moreover, the anticonvulsant drug levetiracetam was found to be valuable in decreasing hyperactivity, impulsivity, aggression, and emotional lability (Rugino and Samsock, 2002) (Table 1)

Abstract Despite promise of its supplementation as both monotherapy and add-on treatment in autism spectrum disorder (ASD), the biobehavioral effects of Palmitoylethanolamide (PEA) in autistic adults have never been explored so far

[137] found that the sesquiterpene CA-4 in the seed extract of Artemisia argyi exerts anti-inflammatory effects through a dual mechanism: 1) Inhibiting the MAPK pathway (phosphorylation of ERK/JNK), down-regulating the expression of iNOS/COX-2, and blocking the polarization of M1 macrophages

Lakkadwala S, Dos Santos Rodrigues B, Sun C, Singh J