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Furthermore, these primary cultures possess an obvious advantage over tumor cell-based model systems, since they more closely reflect the in vivo situation

Endocr Relat Cancer (2014) 21(4):T5766

KPV, derived from -MSH, inhibits NF-B activation and reduces pro-inflammatory cytokines in models of colitis and skin inflammation, offering enhanced gut and systemic anti-inflammatory benefits over GLOWs formulation

Collectively, these investigations suggested the plausibility of modulating the rate of drug release as well as specifically targeting different GSTs by modifying the sulfonamide moiety 128