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ArcA then activates the tricarboxylic acid (TCA) cycle enzymes, leading to dysfunction of TCA cycle and the hyperactivation of respiration (Kohanski et al., 2008)

Upon binding, ivermectin causes a prolonged phase of chloride ion influx, resulting in hyperpolarization, neuronal firing inhibition, paralysis, and ultimately, death of the parasite ( -aminobutyric acid (GABA)-gated chloride channel at higher concentrations, to further inhibit nervous system dysfunction in susceptible parasites (78)

This route provides systemic delivery that can address the underlying immune dysregulation driving psoriasis, not just the local skin manifestation

doi: 10.1038/sj.jhh.1001416 Vanderah TW (2024): Cholinoceptor-Blocking Drugs

LPA stimulates cancer cell proliferation primarily by regulating key cell cycle genes in many different cancers, although receptor engagement varies