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Description

The metalloprotease ADAMTS8 displays antitumor properties through antagonizing EGFR-MEK- ERK signaling and is silenced in carcinomas by CpG methylation

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These include the nuclear factor-B (NF-B) pathway and the NOD-like receptor thermal protein domain associated protein 3 (NLRP3) pathway, which are commonly associated with stress and inflammatory responses (Jiang et al., 2022