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The central role of TJ protein complexes in regulating intestinal permeability has inspired the identification of novel therapeutics that limit their disassembly

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51 Studies of dogs with osteoarthritis have shown that treatment with PEA plus quercetin, at a daily dose of 24 mg/kg body weight for four weeks, or a PEA derivative called palmitoyl-glucosamine plus curcumin for 12 months led to improvements in dog mobility and function and reductions in pain and lameness

Clinical Translation: Subsequent studies have confirmed these laboratory findings in human subjects, showing that topical and systemic GHK-Cu increases measurable collagen deposition and improves skin structural integrity over 8-12 weeks of use