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Preclinical studies suggest that activation of the JAK2/STAT3 pathway contributes to the cardioprotective effects of various agents (Mahdiani et al., 2022), and some compounds may exert their benefits partly through this mechanism (Xiong et al., 2021)

Role of MTHFR C677T gene polymorphism in the susceptibility of schizophrenia: an updated meta-analysis

Understanding this mutation allows functional medicine practitioners to recommend dietary supplementation with a specific form of folate, bypassing the compromised conversion process and reducing the risk of folate deficiency-related diseases