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When iron undergoes oxidation, it results in rust, affecting objects like screws and pipes

Compared with other forms of cell death such as apoptosis, necrosis, and autophagy, ferroptosis exhibits distinct molecular mechanisms and biological features ( Table 1 ): (1) Iron Dependence: Ferroptosis is uniquely triggered by elevated intracellular iron levels, differentiating it from other cell death modes

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The ketone metabolite -hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease

Acta , 2015, vol