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Unlike full-length growth hormone, AOD-9604 selectively stimulates lipolysis without significantly affecting blood glucose levels or growth pathways, making it a valuable tool for studying adipocyte function, fat metabolism, and energy regulation

Minimal immunogenic potential: Long-term studies in rodents and primates report no antibody formation, suggesting a low risk of immune reactions following repeated exposure to the peptide

In a further aspect of the invention, one or more cations chosen from Tables 3a and 3b is contacted with a cell expressing NNMT followed by contacting said cell expressing NNMT with one or more cations of the invention

Understanding how the AOD-9604 peptide works reveals a distinct metabolic approach that targets fat tissue directly without modifying hunger signals, cortisol levels, or appetite hormones

Orally bioavailable lead candidates will be tested in a comprehensive doseranging study to confirm efficacy on obesity and co-morbid endpoints