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In addition, JMJD6 promotes the maintenance of mHSC self-renewal by suppressing OXPHOS and other detrimental mechanisms, such as p53 stabilization 108

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However, while valuable, this model had key limitations, including a lack of reproducible smoke dose delivery, the inability to assess cigarette smoke-induced toxicity in the distal lung, and the absence of essential readouts like trans-barrier electrical resistance (TER), restricting its applicability for studying alveolar-level injuries

Percent antibody-mediated lysis was calculated relative to the max lysis control

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