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Front Microbiol 7:183

IHC and western blot analyses showed that SLC13A3 knockdown had no effect on apoptosis (cleaved caspase 3), but induced autophagy (decreased pmTOR, pp70S6K, and P62

DEM has been shown to cause cytoskeleton disruptions in Clara cells which include cell swelling and membrane bleb formation [90], and disruption in actin and tubulin filaments in hepatocytes [36, 82]

However, high concentrations of the secondary metabolites of the dismutation may cross cellular membranes to generate pro-atherogenic molecules [78,79,80,81]