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Microglial expression of NLRP3, AIM2, and ZBP1 increases after SCI, and caspase-8, caspase-1, RIPK1/RIPK3 are all upregulated in parallel

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Emerging approaches, including antidiabetic drugs, gene therapy, and stem-cell-based treatments, show promise but are not yet disease-modifying or curative [5]

Furthermore, the cleavage of GSDMD (gasdermin D) by CASP1 and CASP11 to produce an N-terminal fragment of GSDMD (GSDMD-N) is a key event driving infection-associated pyroptotic cell death [117]