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A defect in OCTN2 is known to induce primary systemic carnitine deficiency (SCD) a defect that leads to alteration in beta-oxidation of long-chain fatty acids, causing various symptoms, such as myopathy, cardiomyopathy, fatty liver and male infertility[28]

In this line, the composition of the lower respiratory and nasopharyngeal tract, as well as the lungs, is affected by intestinal bacteria that are transported through micro-aspiration and bacterial metabolites circulating in the blood (90)

Other examples include the recently reported ability of nuclear IGF-1R to drive chemotherapy resistance in various types of cancer, and notably, through interactions with nuclear mitotic apparatus (NuMA) protein and regulating p53binding protein 1 (53BP1) dependent DNA doublestrand break repair in colorectal cancer (40)

The junctional adhesion molecule (JAM) family members JAM-2 and JAM-3 associate with the cell polarity protein PAR-3: a possible role for JAMs in endothelial cell polarity

Moreover, it significantly reduced fasting blood glucose levels by approximately 50% and body weight by around 19% in the treated mice