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Clinician Perspective The ADA Standards of Care 2024 state directly: "Routine supplementation with antioxidants, such as vitamins E and C and carotene, is not advised because of lack of evidence of efficacy and concern related to long-term safety." [6] Glutathione is not explicitly addressed in this language, but the guidance reflects a broader evidentiary standard the ADA applies to antioxidant supplements in diabetes management

SIRT6 also suppresses the Warburg effect through the inhibition of the pyruvate kinase M2 (PKM2), thereby regulating glucose homeostasis

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