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Overexpression of miR-20b-5p and miR-106a-5p in serum EVs in insulin-resistant PCOS mouse models could reduce adipocyte differentiation, thereby alleviating lipid metabolism disorders during the process of PCOS development caused by insulin resistance (Hong et al., 2022)

Mechanistically, ascites protects against ferroptosis by increasing lipid droplets via repression of the mitochondrial enzyme, 3-hydroxy-3-methylglutaryl-CoA synthase 2 (HMGCS2) and a subsequent decrease in fatty acid oxidation