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Y., Tai, E

8 Conclusion Osteoarthritis represents most complex whole-joint disorder involving multiple components including articular cartilage, subchondral bone, synovial fluid, synovial membrane, ligaments, tendons, adipose tissue, meniscus, and neurological routes

Because it is an essential, non-covalent cofactor for the Pyruvate Dehydrogenase (PDH) and Alpha-ketoglutarate dehydrogenase (KGDH) complexes, supplementing with highly bioavailable ALA helps unblock the stalled Krebs cycle

2007 Sep;10(3):423-34.

In these studies, the subjects were given 1500 to 3000 mg of acetyl-L-carnitine daily over a period of 3 - 12 months