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Thus, ferroptosis induction could be an important therapeutic strategy to reverse drug resistance in gliomas with high NRF2 and ABCC1 expression

Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model

Missense variants in FIC-related genes are associated with both PFIC and milder disease forms like BRIC, depending on the specific amino acid alteration and the patients genotypic status (homozygous, compound heterozygous, or heterozygous) [19]

It is due to the inactivation of the glutathione (GSH)-dependent antioxidant defense mechanism in cells, and the ability of GPX4 to suppress lipid ROS accumulation is inhibited, which eventually leads to lipid peroxidation and cell death ( Three factors are closely related to ferroptosis: iron, polyunsaturated fatty acids, and amino acids

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