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Other cells, such as epithelial cells, can transdifferentiate to CAFs via MMPs, ROS, and tumor-derived transforming growth factor- (TGF-) (76)

It summarizes key strategies for enhancing MSC adaptability and therapeutic efficacy and proposes standardized parameters for optimizing clinical applications, aiming to provide a theoretical basis and path support for advancing the clinical translation of stem cell therapy in intervertebral disc regeneration

To illustrate, we can point to several double-blind, randomized controlled trials that otherwise failed to support its therapeutic potential for specific diseases

doi: 10.1016/bs.apcsb.2019.02.001 283 HoheneggerMWaldhoerMBeindlWBingBKreimeyerANickelPet al