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Certain substances may share the same cytochrome P450 specificity, thus competitively block their biotransformation activity and lead to accumulation of drugs metabolized by the enzyme

How to Test for Functional Vitamin B12 Deficiency Should Vegetarians Take Creatine to Normalize Homocysteine

These observations are in line with previous studies indicating that a correct P1:P2 ratio reflects a proper replacement of histones with protamines, which correlates significantly with the rate of DNA fragmentation [34]