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In addition, GSSG retained in mitochondria during oxidative stress can lead to the S-gluthionylation of target proteins with mitochondrial dysfunction (20, 21)

Identification of inhibitors of protein-protein interactions has been a major challenge in drug discovery, yet screening strategies, including high-throughput screening and fragment-based drug design, are able to identify compounds suitable for drug development

The deletion of PNPLA2 in adipocytes resulted in reduced PPAR activity and expression of target genes, including lower UCP1 protein levels and when exposed to cold, mice were cold sensitive (140)