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That point is reinforced with the study of Elze et al., where they show a proportion of somatic deficient MMR tumors with somatic exon deletion that is not detectable by sequencing [115]

doi: 10.1016/S2214-109X(14)70227-X

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Therefore, miR-4488, unlike miR-4734, may restrict the proinflammatory response under low stress, including stress originating from basal cell culture conditions, whereas miR-4734 may operate only under relatively stronger stress

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