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Description

Impact of iron overload by transfusion on survival and leukemia transformation of myelodysplastic syndromes in a single center of China

10.1038/s41467-020-15798-5

doi: 10.1093/jxb/erz161

The major translational challenges include achieving sufficient tumor-specific accumulation over healthy tissues (especially for intravenous delivery), overcoming the heterogeneity and adaptability of the TME that may diminish catalytic efficacy, and addressing potential long-term toxicity of Pt accumulation