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Topiramate may also cause a rash with blisters and peeling skin over much of the body that may cause death (toxic epidermal necrolysis)

[4] Chung E, De Young L, Brock GB

The body can increase glutathione by recycling it through a process called the glutathione redox cycle

Highly expressed hepatic isoforms include CYP3A4, CYP2C9, CYP2C8, CYP2E1, and CYP1A2, while CYP2A6, CYP2D6, CYP2B6, CYP2C19, and CYP3A5 show moderate expression, and CYP2J2, CYP1A1, and CYP1B1 are largely extrahepatic