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This syndrome has been reported to be more likely if the patient has abnormal kidney function.9 Although there is some significant debate on this point10, it is generally agreed that patients with abnormal kidney function should start allopurinol at low doses and build up, to ensure that the allopurinol is effectively excreted

Mitrovic and Napier, 2002)

Nausea rates ranged from 20% to 47% depending on dose

In REDEFINE 2, participants lost an average of 13.7% at week 68, compared to 3.4% with placebo

Some patients experience palpitations, a fluttering sensation in the chest, or feelings of nervousness and shakiness