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Ascorbic acid and glutathione in this cycle can maintain protein stability and cell membrane integrity, and together with APX and GR, constitute the ascorbate-glutathione cycle (Miao et al., 2021)

50 Increased neuronal iron disrupts neuromelanin-iron complexes, releasing toxic free iron and causing neuromelanin leakage, which further drives microglial M1 polarization and neurotoxin release