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PML is a ROS sensor activating p53 upon oxidative stress

Category 3: Incorrect Potential Match in EI-MS Corrected by CID An example of low EI-MS score which was incorrectly identified compounds in the NIST database search is coniferyl aldehyde (Figure 5) which was originally identified as 4-methoxy cinnamic acid with EI-MS score of 690

A radiometric assay was performed by RBC using 100M5 nM SAH as an inhibitor positive control

To overcome this constraint, CNS-directed strategies often employ receptor-mediated transcytosis through engineered formats such as bispecific antibodies or brain-shuttle constructs targeting BBB receptors (e.g., TfR or insulin receptor) together with pathological targets such as A or tau, thereby improving brain delivery compared with conventional antibodies (Terstappen et al., 2021)