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To extract more information, raw data from 5072 cells were processed with the Seurat package v2 (Stuart et al., 2019) using the following criteria: min.cells = 10

10.1371/journal.pone.0077023 65 ChenJ.WangL.WuC.HuQ.GuC.YanF.et al (2014b)

Bilirubin is efficiently removed from albumin and internalized by the liver where it is bound initially to cytosolic carrier proteins such as glutathione-S-transferase (ligandin), then glucuronidated and excreted into bile

In the past, both DOPAC and HVA levels in CSF were reported to be significantly lower in PD patients compared to normal subjects, and correlated with motor deficits

This converts a very hydrophobic molecule to a larger hydrophilic derivative that is eliminated via the bile