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Macrophages and intestinal epithelial cells play critical roles in iron metabolism, which can mediate ROS generation (121)

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Their therapeutic effects span across areas such as antimicrobial activity, cells proliferation and migration, synthesis of collagen, and more

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Tissue Eng Regen Med 21:97109 Zhang W, Sun G, Likhodii S, Liu M, Aref-Eshghi E, Harper PE, Martin G, Furey A, Green R, Randell E et al (2016) Metabolomic analysis of human plasma reveals that arginine is depleted in knee osteoarthritis patients