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The deficiency in the production of glutathione leads to break down of red blood cells, enlargement of the spleen, gallstones,and after many years can lead to mental deterioration.*

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These effects typically resolve within the first two weeks

Overall, the evidence base for Rhodiola rosea is mechanistically coherent and clinically promising, but larger, adequately powered head-to-head trials are needed to more clearly define its therapeutic positioning

In a clinical study, L-serine was associated with a slower rate of clinical worsening in hereditary sensory and autonomic neuropathy type 1 65