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Abbreviations DHA: Docosahexaenoic acid DPP4: Dipeptidyl peptidase-4 FBG: Fasting blood glucose GSH: Glutathione H&E: Hematoxylin and eosin HOMA-IR: Homeostasis model assessment-insulin resistance IDF: International diabetes federation MDA: Malondialdehyde PGG: Postprandial blood glucose PI3K: Phosphatidylinositol 3-kinase ROS: Reactive oxygen species T2D: Type 2 diabetes TG: Triglycerides GPx: Glutathione peroxidase SOD: Super oxide dismutase References Sun, H

Additionally, analogues containing the quinolinium scaffold lacked inhibitory activity against enzymes in the NAD + salvage pathway that bind nicotinamide-containing substrate, including NAMPT[27, 32] and the NAD + -dependent SIRT1 enzyme, which deacetylates NAD + to produce NA, a product inhibitor of SIRT1.[33] These results suggest that quinolinium-based NNMT inhibitors achieve selectivity by specifically interacting with the NA-binding pocket of NNMT,[17] unlike several known non-selective methyltransferase inhibitors that interact with the SAM-binding pocket, which is highly conserved among SAM-dependent methyltransferases.[34, 35] Membrane-permeable NNMT inhibitors reduced intracellular 1-MNA levels in a concentration-dependent manner and at pharmacologically relevant concentrations that did not impact cell viability, suggesting these small molecules interact directly with NNMT in cells

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K.SchousboeA.Steve WhiteH

In addition, sulfonamide antimicrobials contain a substituted ring at the N1-position