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Researchers introduced a ketone functional group into the erastin structure to obtain the carbonyl analog imidazole ketone erastin (IKE), which is more effective at inducing ferroptosis [128]

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However, in AML harboring TP53 mutations, DTP cells are arrested in G2/M phases of cell cycle, elimusertib inhibits the expression of the G2/M-phase cell-cycle checkpoints regulators (including cdc25c, p-CDK1, and Cyclin b) to reactivate the cell cycle thereby resensitize to treatments (Kim et al., 2024)

MRPs prepared from fermentation of milk proteins by lactic acid bacteria show higher antioxidant activity than the intact milk protein, low intracellular ROS production and sustain reduced-GSH levels in hepatocytes 630